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Comprehensive Male Fertility Evaluation

With 50% of difficulty with conception being related to the male and up to 35% of couples having more than one problem, the male work-up is equally as important as the female.

Prior to any evaluation, a complete medical history and review of any pertinent medical records is essential. Unfortunately, in the case of male infertility, only 10% of the time, a cause can be identified and most of the time the only indication of a problem is an abnormal semen analysis. In most cases, you are dealing with a normal healthy male whose only problem is poor "sperm parameters". Besides a complete semen analysis, a thorough medical history is essential.

Semen Analysis

About 10% of the time an abnormal Semen Analysis (SA) can result from:

  • Previous history of an undescended testicle(s).
  • Family history of cystic fibrosis
  • Any bladder surgery as a child
  • Hernia surgery as a child
  • Certain infections like mumps, epididymitis, urethritis and/or prostatitis
  • Severe trauma to the testicles
  • Alcohol use
  • Marijuana use
  • Certain medications
  • High fever 3 months prior to the Semen Analysis
  • Varicocele
  • Congenital absence of the vas deferens
  • Exposure to certain chemicals and toxins
  • Anabolic steroid (testosterone) and/or human growth hormone (hGH) use

Besides doing a complete semen analysis using Krueger's Strict Morphology Testing and a thorough medical history, hormone testing and urologic examination may be beneficial. It is important to ask the man if he is using alcohol or marijuana, taking any medications, including steroids and/or hGH, has had any surgery, infection in the testicles (mumps), undescended testicle(s), significant trauma to the genital area and whether or not he has normal sex drive (decreased sex drive may be a sign of elevated Prolactin or TSH Levels).

Normal Male Anatomy

Graphic representation of normal male anatomy

Hormone testing would initially include FSH, LH, Testosterone, Estrogen and Prolactin. Urologic examination can identify a Varicocele (dilated veins in the scrotum), Hydrocele (fluid filled sac in the testicles), smaller an average testicles or the absence of the vas deferens (the tube connecting the testicles to the penis).

Abnormal Semen Analysis

An abnormal semen analysis either show:

  • Oligospermia - decreased numbers of sperm
  • Zoospermia - the absence of sperm but the presence of semen
  • Aspermia - the absence of sperm and semen
  • Asthenospermia - increased amount of non motile sperm
  • Teratospermia - increased amount of morphological abnormal sperm

If no sperm are found on the Semen Analysis, and the FSH level is normal or only slightly elevated, 40+% of the time, enough spermare found on a testicular to use for In Vitro Fertilization (ICSI, MESA/TESA) and donor sperm does not have to be used.

Variocele Repairs

It has been the experience at Arizona Center for Fertility Studies, that even if a varicocele is diagnosed on a physical examination and surgery recommended, contrary to some opinions, we have seen little to no improvement in pregnancy rates, although there can be some change in sperm parameters. Therefore, Arizona Center for Fertility Studies does not recommend varicocele repairs.

Fertility Medications

Some clinics will recommend the use of fertility medication, mainly Clomid, in men with poor sperm counts. Again, it has been the experience at Arizona Center for Fertility Studies, that these medications show little to no improvement in sperm parameters and statistically do not improve pregnancy rates. However, there will be a small percentage of men that may respond to drug treatment and should be given the option of whether or not they want to try the medication. It takes about 75 days to make new sperm and about 15-26 days for those sperm to gain motility and fertilizing ability; therefore, treatment has to be continued for at least 3 months to see if there is any improvement and then continued if there is. Most men do not want to wait this long for a very small chance that there will be a significant improvement in their sperm parameters that could result in a successful pregnancy.

Substance Use

If the man drinks alcohol and/or uses marijuana, there is direct evidence that either can effect spermatogenesis or the production, motility and morphology of the sperm. Although there is no guarantee that completely stopping alcohol and/or marijuana will improve spermatogenesis, there is clear evidence that it "could" be beneficial and the strong recommendation at Arizona Center for Fertility Studies is to stop completely, not cut down. It is impossible in any individual to determine "how much is too much or how little is okay". There is no question that anabolic steroids (testosterone) and/or human growth hormone (hGH) use severely effect sperm parameters, and in many cases, sperm counts fall close to zero or zero.

Popular Myths About Male Infertility

Let's put to rest, once and for all some popular myths - that tight underwear, as opposed to boxer shorts, hot tubs and too much sex cause male infertility. THEY DO NOT!

The Bottom Line

"Bottom line in male infertility, except in a few isolated situations, that the worse the sperm parameters, the closer you need to get the sperm to the egg. Sorry guys, but it is all about the egg".

It is an established fact that you need a certain of amount of Total Motile Normal Sperm (TMNS) to get the job done. The thinking that it only takes one is only partially true. Sure, it takes one to fertilize an egg, but it takes millions to get the job done. The following is meant to be a guide to the amount of Total Motile Normal Sperm (TMNS) needed to be have a successful pregnancy:

Intercourse 100's of million of Total Motile Normal Sperm (TMNS)
IUI Greater than or equal to 5 million Total Motile Normal Sperm (TMNS)
IVF 250-300,000 Total Motile Normal Sperm (TMNS) if fertilizing in the dish
ICSI 1 sperm per egg
Donor sperm None

Anything less than these numbers for each category of treatment will most likely result in that treatment option being unsuccessful.

To calculate this number use the following formula:

  • Multiple the total volume of sperm in cc by the total number of sperm reported;
  • Than multiply that by the percentage of the normal motility
    (a report of 50% motility would be by .50);
  • Than multiply that number by the percentage of the normal morphology (a report of 9% morphology would be by .09);
  • And divide the resulting number by 1/2 for the amount of sperm that are lost in the vagina/cervix or after sperm washing for insemination.
  • The resulting total will be the Total Motile Normal Sperm (TMNS) count.

Here is an example of how to figure out your partner's Total Motile Normal Sperm (TMNS) count from this sample SA:

Volume 2.4 cc
Numbers 34 million/cc
Motility 47%
Normal 6%

To calculate Total Motile Normal Sperm (TMNS) count: 2.4 x 34 = 81.6 x .47 = 38.352 x .06 = 2.30 divided by 1/2= 1.15

The Total Motile Normal Sperm (TMNS) count is 1.15 million total motile normal sperm.

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Call us to learn more about Comprehensive Male Fertility Evaluation and the fertility treatments Arizona Center for Fertility Studies offers to patients in Scottsdale, Phoenix, Mesa, Tempe, Gilbert, Chandler, and Glendale Arizona.

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